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These cells can develop into a number of different cell types, including muscle, bone, and, importantly, cartilage. The scientists wanted to know whether it might be possible to regenerate knee cartilage using mesenchymal stromal cells (MSCs).
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They published their results in the journal STEM CELLS Translational Medicine.
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Recently, a group of researchers from the Krembil Research Institute, University Health Network in Toronto, Canada looked into the potential use of stem cells to treat KOA. In some cases there are reported improvements to cartilage morphology. MSCs have been tested in a number of smaller-phase trials and are effective in alleviating pain and patient symptoms. Mesenchymal stromal cells (MSCs) are a leading investigational therapeutic product because of their multiple mechanisms of action. When OA progresses to the end stages and nonoperative care fails, total joint replacement can be an effective alternative. Patients with OA are initially treated with a combination of physical therapy, activity modification, weight loss, nonsteroidal anti-inflammatories and/or intra-articular injections with the goal of symptom modification. People born with malformed joints or defective cartilage have increased risk of OA. Some people inherit a tendency to develop OA. If your job or sport places repetitive stress on a joint, it may develop OA. Previous injuries, such as one that can occur playing sports or an accident can increase the risk of OA. Increased weight adds stress to the joints.
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It causes changes in the bone and deterioration of the connective tissues that hold the joint together and attach muscle to bone.įactors that increase the risk of OA include: It affects not only the cartilage, but also the entire joint. OA has often been referred to as wear and tear disease. Eventually, cartilage wears down completely and bone will rub on bone. Osteoarthritis occurs when the cartilage that cushions the ends of bones in the joints gradually deteriorates.
#Stem cell treatment for osteoarthritis full
You might not be able to move your joint through its full range of motion. Your joint might feel tender when you apply light pressure to or near it. Joint stiffness might be most noticeable upon awakening or after being inactive. Affected joints might hurt during or after movement. Symptoms often develop slowly and worsen over time. Staying active, maintaining a healthy weight and receiving certain treatments might slow progression of the disease and help improve pain and joint function. Osteoarthritis symptoms can usually be managed, although the damage to joints can’t be reversed. Although osteoarthritis can damage any joint, the disorder most commonly affects joints in your hands, knees, hips and spine. Osteoarthritis is predominantly a disease of older age, affecting more than 10 million people over the age of 60 years. According to the Centers for Disease Control and Prevention (CDC), osteoarthritis affects an estimated 30 million people in the United States. Osteoarthritis (OA) is a progressive and debilitating joint disease that is expected to affect up to 25% of the population by 2040 and represents an enormous socioeconomic health care burden.